LACTIC ACIDOSIS

LACTIC ACIDOSIS HAS BEEN REPORTED WITH THE USE OF ZYVOX

Although these reports have primarily been in patients treated for longer than the maximum recommended duration of 28 days, these events have also been reported in patients receiving shorter courses of therapy.

In reported cases, patients experienced repeated episodes of:

* Nausea
* Vomiting

Patients who develop recurrent nausea or vomiting, unexplained acidosis, or a low bicarbonate level while receiving ZYVOX should receive immediate medical evaluation.

Many factors can contribute to the development of lactic acidosis. When it has occurred during ZYVOX treatment, however, in most cases it was reversible upon discontinuation of therapy.